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Glaucoma Physician

Article

Study Establishes Normative OCT Ranges for RNFL and CDR Asymmetry

Data from participants in the Framingham Heart Study may help clinicians distinguish true pathologic asymmetry from expected physiologic variation when interpreting OCT findings.

Glaucoma Physician June 6, 2025 Vol 29, Issue June 2025
5 Key Takeaways

  • 1

    A study establishes normative ranges for interocular differences in RNFL thickness and CDR using OCT data from the Framingham Heart Study.

  • 2

    The mean interocular difference in RNFL thickness was 0.4 µm, with a 95% range from -12.7 µm to 12.7 µm considered physiologically normal.

  • 3

    Significant predictors of RNFL asymmetry included differences in rim area and signal strength, highlighting the impact of image quality.

  • 4

    The study provides population-based benchmarks that may enhance clinical interpretation of asymmetry in RNFL and CDR.

  • 5

    Findings emphasize the need for comprehensive assessments of optic nerve health, incorporating OCT data with other diagnostic indicators.