5 Key Takeaways

• 1

  Epigenetic age acceleration is significantly associated with the rate of glaucoma progression in primary open-angle glaucoma patients.

• 2

  Fast progressors of glaucoma exhibited greater epigenetic aging, as indicated by DNA methylation patterns, compared to slow progressors.

• 3

  The study utilized epigenetic clocks to calculate biological age, revealing that faster biological aging correlates with faster glaucoma progression.

• 4

  Each additional year of epigenetic age acceleration increased the odds of fast glaucoma progression by 15%, even after adjusting for confounders.

• 5

  The findings suggest that biological aging may influence optic nerve susceptibility in glaucoma, independent of traditional risk factors like IOP.