Targeting Episcleral Venous Pressure to Reduce IOP

By directly targeting distal outflow and EVP, ATP-sensitive potassium channel openers like QLS-111 could redefine treatment.

Michael P. Fautsch Barbara M. Wirostko SriniVas R. Sadda FARVO

Glaucoma Physician March 1, 2025 Vol 29, Issue March 2025 Page(s): 15-16

Objective:

Emphasize the significance of targeting EVP in glaucoma treatment.

Key Findings:

Add specific data from studies to support findings.

Interpretation:

Strengthen the connection to treatment implications of targeting EVP.

Limitations:

Provide more context on the nature of further studies needed.

Conclusion:

Reiterate the potential impact of QLS-111 on existing treatment paradigms.

Michael P. Fautsch

Specialties: Glaucoma

Bio: Michael P. Fautsch, PhD, writes about glaucoma physiology and therapeutic approaches to lowering intraocular pressure. His work in Glaucoma Physician has addressed episcleral venous pressure, distal aqueous outflow, and the potential role of ATP-sensitive potassium channel openers in glaucoma treatment.

Barbara M. Wirostko

Specialties: Glaucoma

Bio: Barbara M. Wirostko, MD, FARVO, is an ophthalmology author focused on glaucoma management. Her work in Ophthalmology Management has addressed home tonometry, intraocular pressure monitoring, and the role of out-of-office measurements in identifying pressure fluctuations that may influence glaucoma treatment decisions.

SriniVas R. Sadda

Specialties: Medical retina

Bio: SriniVas R. Sadda, MD, FARVO, is an ophthalmology author focused on medical retina topics, including neovascular age-related macular degeneration and diabetic macular edema. His work in Retinal Physician discusses anti-VEGF therapy, retinal thickness variability, fluid fluctuations, and their relationship to long-term visual acuity outcomes.

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